Endocrine Abstracts

Background: Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited tumour syndrome with an important phenotypic variability. Genetic testing for VHL is simple and accurate.Objective: In this study, we investigated the relationships between genotype and phenotype in a series of patients with different VHL gene mutations.Method: This was a retrospective analysis of the clinical and molecular characteristics of 15 VHL pati...

Introduction: The poor prognosis of patients with Cushing’s syndrome due to ectopic ACTH secretion (ECS) requires prompt diagnosis and management of the disease. Objectives: To find clinical and biological differences between ECS and pituitary Cushing’s disease (CD) at diagnosis and to determine whether any of them may be a potential predictor for early suspicion of ECS. Methods: This was a retrospective case-nested study...

Introduction: The Incidental diagnosis of non-functioning pituitary macroadenomas (NPFMA) is becoming more prevalent with the spread of modern imaging techniques. More clinical data about their natural history and surgical results are needed. Methods: We retrospectively analyzed medical files of patients referred to our clinic for an incidental NFPMA between 2010 and 2019. In particular, we compared patients that experienced tumor growth or not during su...

Background: Insulinomas are the most common functional neuroendocrine tumours of the pancreas. Hypoglycaemic manifestations are highly variable and largely independent on tumour size and severity of insulin hypersecretion.Objectives: In this study we investigated the clinical, biological and tumoural characteristics of a large series of patients with insulinoma and we evaluated the sensitivity of peripheral tissues to insulin before and after surgery.</p...

Objectives: Surgery of pheochromocytomas (PC) still carries a high risk of hemodynamic complications during the perioperative period. We aimed to evaluate the influence of their secretory phenotype and preoperative alpha-blocker treatment on surgical outcome.Design: A retrospective monocentric study at a tertiary medical center.Patients: 80 consecutive patients operated for an adrenal PC between 1988 and 2018.<p class="abstext"...